The Role of CaMKK2 in Whole-Body Metabolism and Bone Remodeling
Public DepositedMLA citation style (9th ed.)
. 2021. marian.hykucommons.org/concern/generic_works/5b12da98-991f-49fd-b76f-9a911dde7cdc?q=12/18/1959%200:00. The Role of Camkk2 In Whole-body Metabolism and Bone Remodeling.APA citation style (7th ed.)
(2021). The Role of CaMKK2 in Whole-Body Metabolism and Bone Remodeling. https://marian.hykucommons.org/concern/generic_works/5b12da98-991f-49fd-b76f-9a911dde7cdc?q=12/18/1959%200:00Chicago citation style (CMOS 17, author-date)
The Role of Camkk2 In Whole-Body Metabolism and Bone Remodeling. 2021. https://marian.hykucommons.org/concern/generic_works/5b12da98-991f-49fd-b76f-9a911dde7cdc?q=12/18/1959%200:00.Note: These citations are programmatically generated and may be incomplete.
Obesity and metabolic dysfunction negatively impacts many tissues, including the skeleton. Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine protein kinase and key regulator of whole-body energy homeostasis. Previous studies have shown that male Camkk2-/- mice are protected from high-fat diet induced obesity, glucose intolerance and insulin resistance. CaMKK2 regulates hypothalamic control of appetite, hepatic gluconeogenesis, and insulin production by pancreatic β cells. Deletion of CaMKK2 has also been shown to enhance bone mass and strength in mice. The skeleton is recognized as a highly dynamic and metabolic tissue capable of regulating systemic glucose metabolism. The role of CaMKK2 in bone-mediate regulation of whole-body metabolism is unknown.
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